2. Signaling Pathways
  3. GPCR/G Protein
  4. TSH Receptor
  5. TSH Receptor Agonist

TSH Receptor Agonist

TSH Receptor Agonists (4):

Cat. No. Product Name Effect Purity
  • HY-114116
    ML-109
    		Agonist 99.02%
    ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM.
  • HY-114918
    MS438
    		Agonist 99.85%
    MS438 is a potent thyrotropin receptor (TSHR) agonist with an EC50 of 53 nM. MS438 binds to the serpentine portion of the TSHR. MS438 induces T4 secretion in mice.
  • HY-100271
    Org41841
    		Agonist 99.77%
    Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.
  • HY-W679754R
    Pentacosafluorotridecanoic Acid (Standard)
    		Agonist
    Pentacosafluorotridecanoic Acid (Standard) is the analytical standard of Pentacosafluorotridecanoic Acid. This product is intended for research and analytical applications. Perfluorotridecanoic acid (PFTrDA) is a perfluoroalkyl substance (PFAS). Embryo larval exposure of PFTrDA induces yolk sac edema and increases mRNA expression of thyroid hormone synthesis genes, including tshβ, in zebrafish when used at concentrations of 0.1 and 0.3 mg/L, respectively. PFTrDA (10 mg/kg) decreases serum testosterone and luteinizing hormone levels, testis palmitic acid, linoleic acid, and oleic acid levels, and the number of Leydig cells in rats in late puberty. Maternal plasma levels of PFTrDA during gestation are positively associated with the development of eczema in female, but not male, infants, and liver levels of PFTrDA are higher in cancerous human livers compared with non-cancerous human livers. It has been found in marine mammals.